منابع مشابه
Erlotinib-induced Adverse Skin Reactions
Erlotinib is low molecular-weight quinazolin derivatives which selectively inhibit the epidermal growth factor receptor (EGF-R) tyrosine kinase activity of the intracellular domain, block autophosphorylation and the subsequent signaling cascades. EGF-R is expressed on basal keratinocytes, sebocytes, the outer root sheath of hairs, and endothelial cells in the skin, and plays important roles in ...
متن کامل[Adverse cutaneous reactions to erlotinib].
INTRODUCTION Erlotinib is an inhibitor of human epidermal growth factor approved for treating non-small cell lung cancer. The aim of this prospective observational study was to determine the prevalence of adverse cutaneous reactions caused by erlotinib and assess the management of such effects. METHODS Eleven patients with lung cancer and 1 with ovarian cancer received erlotinib at a dose of ...
متن کاملAspirin induced adverse skin reactions: new pathophysiological aspects.
Clinically, aspirin induced adverse skin reactions resemble true immunologically mediated allergic reactions. However, it is well accepted that aspirin intolerance is not mediated by specific IgE antibodies. The exact mechanisms involved are far from clear 2 and therefore no reliable diagnostic in vitro tests exist, and risky and time consuming provocation tests are regarded as the diagnostic g...
متن کاملDrug-induced Skin Reactions
Objective Recently, skin reactions to luteinizing hormone-releasing hormone (LH-RH) agonist therapy were reported after the 3-month depot type was released. We evaluate skin reactions to the 3-month depot type of LHRH agonist by questionnaires obtained from patients with prostate cancer who had been given a subcutaneous injection of LH-RH agonist. Materials and Methods A questionnaire regarding...
متن کاملDrug-induced skin reactions
Cutaneous drug eruptions are one of the most common types of adverse reaction to drug therapy, with an overall incidence rate of 2–3% in hospitalised patients.1–3 Almost any medicine can induce skin reactions, and certain drug classes, such as non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics and antiepileptics, have drug eruption rates approaching 1–5%.4 Although most drug-related sk...
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ژورنال
عنوان ژورنال: The Open Allergy Journal
سال: 2013
ISSN: 1874-8384
DOI: 10.2174/1874838420130904002